There’s a new launcher in town, and it comes from one of the most inexpensive phones in the world. Xiaomi launched the brand Poco this year to bring about some competition in the mid-range smartphone space. More specifically they wanted to bring heat to India, where OnePlus currently dominates. With the Poco Launcher, you can see what sort of Android software experience this Poco is really serving up. The Poco Launcher is a full launcher, made to bring the Poco software experience – on top of Android – around the world. With this launcher, users will find a surprisingly familiar layout. This launcher looks a whole lot like Miui, Xiaomi’s software experience on Android. That’s because it basically is just that – it’s called “MIUI for Poco.” In essence, you’re getting a parred-down version of MIUI for all manner of Android smartphone.This app is meant to make the user’s Android experience fast. The description given by Poco is “POCO Launcher is born for breakneck speeds. Forget about slow system animations!” No more animations to waste your precious time, now is the time for speed!This launcher is free, and it provides several key features which are (for the most part) hidden behind up-front-pay launcher apps. Unless you’ve found a gem, in which case, let me know! Included in this launcher are the following features:AdChoices广告• Clean Home Screen by tossing ALL apps in app drawer.• Icon Customization (use packs of several sorts)• Hide App Icons (shhh! Nobody knows you play Cwayze Cupcakes!)• Extended Search with icon color categories, app recommendations, other tweak-able features• App Grouping by category automatically, custom groups, etcThe only bummer about this app is its semi-limited availability. Right out the gate, it’s part of an “Early Access Program” and – as of the release of this article – the program is “currently full.” The good news is that “space may open up later.” The even better news is that it probably won’t be long before the app is open to everyone in the world, no invite required.You can find this launcher over on Google Play right now. But you probably won’t be able to tap it to install, unless you’re very lucky. Let us know if you’re feeling lucky, punk, and get to download the app as such. You could also always just take your own life into your hands and go over to APKMirror to download the app. But you didn’t hear it from me! Story TimelineWhy POCO F1 is the new Android iPhonePoco F1 can beat OnePlus 6: 10 points!POCOPHONE F1 global rollout: why it mattersPOCO F1 teardown will make you wish other phones are like it
The LA Auto Show 2018 wasn’t lacking in alluring supercars, concepts, and EVs, but some of the cars stood head and shoulders above the rest. Whether for their electric ambition, for putting a fresh spin on a classic, or just for being drop-dead delicious, these best-of-show models each have something to recommend them. Read on for our top five most noteworthy cars of the LA Auto Show 2018. Story TimelineThe 2020 BMW M340i is a compelling return to formThe new 2020 Porsche 911 is all about how you feelThe 2020 Lincoln Aviator pulls out the stops to sweep up in midsize SUVsForget hamsters, the 2020 Kia Soul EV is charming by itself Concept cars are easy grist for the auto show mill: it’s easy to get a few quick headlines for an expensive, impractical one-off. The Audi e-tron GT, though, may be a concept car but it’s one with production firmly in mind. In fact, the automaker expects to have a production version by late 2020. AdChoices广告That’s impressive, considering you’re looking at a seductive grand tourer with Quattro all-wheel drive, around 250 miles of range, and a super-fast charging system that could take you from zero to 80-percent in about twenty minutes. 0-62 mph would take around 3.5 seconds, meanwhile, with a top speed electronically limited to 149 mph. All with four people cosseted in plenty of cabin space. We can’t wait.2019 Mazda3Undoubtedly one of the most important models in Mazda’s line-up, the 2019 Mazda3 gets a few privileges in return. For a start it debuts the latest iteration of the automaker’s newest version of Kodo, the stylish design language that has made Mazda’s most recent models some of the best-looking mainstream cars on the road. Second, it brings the company’s fiendishly clever Skyactiv-X engine technology to dealerships. It promises significantly more economy than a gas engine but with the torque of a diesel. That’s wrapped up in two handsome designs, a hatchback and a sedan, and a cabin that’s a step above most other cars in the class. The big question is whether the fact that it’s a mild hybrid – recuperated power is used to run the Mazda3’s electrical systems, but not actually in propulsion – will count against it. Rivian R1T and R1SRivian may not be a name you’re familiar with now in EVs, but by late 2020 the startup is hoping to be as recognizable as Tesla. That ambition comes with not one but two all-new models, the Rivian R1T pickup truck and its sibling, the R1S SUV. Both take advantage of the automaker’s new “skateboard” architecture. That effectively packages up the four electric motors, braking system, battery, inverters, and all the rest of the drivetrain components into a lower slice. On top of that, Rivian has the flexibility to mount whichever body style it prefers. So, the R1T gets a pickup body with numerous extra cargo spaces – including a front trunk and a body-spanning nook where a gasoline truck’s fuel tank would be – while the R1S has space for seven and their cargo. 2019 Honda PassportDoes the world need another 5-seater family SUV? That’s the wrong question to be asking when it comes to the 2019 Honda Passport. The right one is “just how popular will this new mini-Pilot be?” and we suspect the answer is “very popular indeed.” It’s smaller, but still packs plenty of space for both passengers and luggage. Clever cargo boxes, bins, and cubbies should help keep things organized, while Honda’s latest infotainment system and Honda Sensing as standard tick the tech and active safety boxes. It’s a category Honda is perennially successful in, and for good reason, and the 2019 Passport should be no different.You can find all of our LA Auto Show 2018 coverage in the SlashGear Cars hub 2020 Jeep GladiatorTo say enthusiasts have been waiting a long time for a Wrangler pickup is a serious understatement. Jeep, though, has finally delivered, and better still it looks like it hasn’t just done some underwhelming badge-engineering. The 2020 Jeep Gladiator looks like the real deal. 7,650 pounds of towing capacity, and up to 1,600 pounds of payload. A 3.6-liter V6 as standard, with a 3.0-liter diesel following in 2020 with a healthy 442 lb-ft of torque. And a choice of capable 4×4 systems, including Tru-Lok locking differentials, beefy 33-inch tires, and more. Audi e-tron GT Concept
Story TimelineAirbus Mars rover will send samples back to EarthAirbus A380 aircraft deliveries to end in 2021Reasons why the Airbus A380 failed According to Airbus, its flapping wing tips involve a semi-aeroelastic hinge concept that is designed to reduce both overall wing weight and drag while also helping deal with the effects of strong wind gusts and turbulence. The company has installed and tested the wing tip concept on its AlbatrossOne remote-controlled aircraft.The test flight was a proof of concept, the company said on Thursday, explaining that it will conduct additional tests of the design before scaling up the model to bigger sizes. This represents the first aircraft test of this technology for use against turbulence and wind gusts, and it may revolutionize the future of aircraft wings.According to the company, using flapping tips on aircraft wings reduces overall weight of the vehicle by reducing the massive loads transmitted to the fuselage in turbulent conditions. As a result, Airbus explained, the wing tips may allow for longer, lighter wings, which reduces drag and potentially improves fuel efficiency.A 20-month development program led to the first AlbatrossOne demonstrator test flights, which were wrapped up in February. Both lock and unlocked wing tip positions were tested, and planned future tests will combine both of those states to examine how the transition takes place. Airbus is working on a unique airplane design that involves flapping wing tips, something found on military jets but not commercial aircraft. The company successfully tested a remote-controlled scale-model plane fitted with the flapping wing tips, the company revealed this week. The demonstrator aircraft was based on the company’s A321 plane.
First Edition: June 16, 2014 Today’s headlines include more analysis of the events that led to a resolution of Virginia’s budget impasse and an end — at least for now — to Gov. Terry McAuliffe’s hope to expand Medicaid. Kaiser Health News: Say What? Many Patients Struggling To Learn The Foreign Language Of Health InsuranceKaiser Health News staff writer Anna Gorman reports: “Health officials have spent much of the past year promoting the Affordable Care Act and enrolling people in coverage. Now they need to help consumers understand the basics of health insurance and how to use their policies, health care providers and researchers say” (Gorman, 6/16). Read the story.Kaiser Health News: Health Data Geeks Get Their DayReporting for Kaiser Health News, in partnership with NPR, Eric Whitney reports: “Venture capitalists are pouring more money than ever before into digital health start-ups, more than $2 billion so far this year alone, according to the venture capital firm Rock Health. They are betting that entrepreneurs can help doctors, hospitals and insurers become leaner – which the Affordable Care Act strongly encourages” (Whitney, 6/16). Read the story. The New York Times: Thousands To Be Questioned On Eligibility For Health Insurance Subsidies Of the eight million people who signed up for private health plans through insurance exchanges under the new health care law, two million reported personal information that differed from data in government records, according to federal officials and Serco, the company hired to resolve such inconsistencies. The government is asking consumers for additional documents … People who do not provide the information risk losing their subsidized coverage and may have to repay subsidies next April (Pear, 6/15).The Washington Post: In Virginia, The Road To A Budget Comes With Twists And TurnsVirginia seemed hopelessly locked in a partisan budget and Medicaid standoff, careening toward its first-ever government shutdown. Yet for weeks behind the scenes, a handful of lawmakers were hammering out a deal. … Even as the GOP took full control of the legislature, thwarting Medicaid expansion and dimming the legislative prospects for McAuliffe’s entire term, the Republican Party’s insecurities and internal fractures were on vivid display. Conservative Republicans, already suspicious that McAuliffe will attempt through executive order what he cannot win through the legislature, made it clear that they also distrust the GOP pragmatists in their midst (Vozzella, 6/15).The Associated Press: McAuliffe Blasts Tea Party After Budget VoteAll eyes are now on McAuliffe to see what he does with the budget and how he responds to a major setback of one of the top priorities of his young administration. The Affordable Care Act allows states to expand Medicaid eligibility to low-income residents with the federal government paying for most of the expense. Democrats largely favor expansion, saying that would help the working poor, while Republicans argue the state can’t afford a large increase of a costly entitlement program (6/13).The Washington Post: Gov. Rick Snyder Could Be The Country’s Most Unusual Republican. Can He Save Detroit? Like some other GOP governors, Snyder has signed controversial right-to-work legislation preventing unions from requiring workers to pay dues — a crushing defeat for organized labor in a state that was once a hub of union power. Working with a GOP-controlled legislature, he also has cut unemployment benefits and slashed business taxes while imposing a new tax on pensioners. But unlike many Republican governors, he pushed to expand Medicaid and is encouraging immigration of high-skill workers. He vetoed legislation requiring voters to have government-issued identification. And while Snyder forced Detroit into bankruptcy, he has become perhaps the most influential advocate for an aid plan to put the city back on sound financial footing (Fletcher, 6/13).Politico: Hobby Lobby Aims For Obamacare Win, Christian NationThe evangelical owners of Hobby Lobby made a fortune selling crafts supplies and made headlines fighting government-mandated birth control coverage. They’re also using their billions to sell the American public on the literal truth of Scripture — through a public-school Bible curriculum, a huge museum around the corner from the Smithsonian and public forums on the faith of the founding fathers. The Green family may be best known in secular circles for their lawsuit against Obamacare, a high-stakes — and highly political — case that could undercut the administration’s goal of setting minimum standards for health care coverage. By the end of this month, the Supreme Court will decide if the federal government can force the Greens to include methods of contraception they deem sinful as part of employees’ health insurance (Simon, 6/16).The Associated Press: Supreme Court To Decide
Raleigh News & Observer: NC Medicaid Holdout Puts Infants At Risk The News&Observer: Giving NC Babies A Better Chance ObamaCare’s image of invincibility is increasingly being exposed as a political illusion, at least for those with permission to be honest about the evidence. Witness the heretofore unknown phenomenon of a “free” entitlement that its beneficiaries can’t afford or don’t want. This month the Health and Human Services Department dramatically discounted its internal estimate of how many people will join the state insurance exchanges in 2016. There are about 9.1 million enrollees today, and the consensus estimate—by the Congressional Budget Office, the Medicare actuary and independent analysts like Rand Corp.—was that participation would surge to some 20 million. But HHS now expects enrollment to grow to between merely 9.4 million and 11.4 million. (10/25) Viewpoints: Health Law Enrollment Lags; Paul Ryan’s Challenge; New Mammography Debate A selection of opinions on health care from around the country. [S]ome Freedom Caucus members consider Ryan … to be dangerously moderate too. Never mind that Mitt Romney chose Ryan as his running mate in 2012 because the congressman had championed bills to slash domestic spending and turn Medicare into a voucher plan. Ultras in the Freedom Caucus distrust Ryan because, as chairman of the House’s tax-writing committee, he made a bipartisan budget deal to keep the government running in 2013. … Tea party organizations are already raising money from supporters with appeals to stop any more Ryanesque budget deals. The GOP presidential campaign will complicate the new speaker’s life too. Already, Sen. Ted Cruz (R-Texas) has demanded that the House include the complete repeal of Obama’s healthcare plan in any budget deal, a reprise of his demand that touched off a 16-day government shutdown in 2013. (Doyle McManus, 10/25) While Republican leaders in Raleigh refuse to expand Medicaid, Dr. Dorothy DeGuzman spends her days in rural Yancey County dealing with the consequences. DeGuzman works for Celo Health Center in Burnsville, a nonprofit, community-owned family practice that serves low-income people in the mountainous county north of Asheville. Most of the center’s patients do not have private health insurance, and their health reflects a lack of access to doctors and preventative programs that would help reduce obesity, hypertension, smoking and substance abuse. The medical care gap shows up most profoundly in the pregnant women DeGuzman sees. (Ned Barnett, 10/24) After decades of inaction, concern about the use of antibiotics in animal agriculture is finally gaining traction, not because of federal regulations or congressional legislation, but because smart people around the nation are listening to consumers and thinking creatively about new ways of doing things. Antibiotic resistance is a serious global problem that is growing worse. (10/25) The New York Times: Shifting Advice On Mammograms The American Cancer Society issued new guidelines last week saying that women with an average risk of breast cancer should start having mammograms at 45, five years later than it had long advocated. This presents yet another wrinkle for women who are trying to make informed decisions about their health care, especially when other respected groups suggest earlier or later ages. (10/26) Over the past three decades, more and more women have opted to get mammograms, which, despite some discomfort and anxiety, provide the best way to detect breast cancer early. The system has worked: In the same period, the rate of breast cancer deaths has been cut by one-third. That can’t be coincidence, and most everyone, including the influential American Cancer Society, agrees that early detection saves lives. (10/25) The significance became clear after I took care of my own red blanket patients: It was a marker of status. At that hospital, patient relations gave them to some C.E.O.s, celebrities and trustees’ friends. Although we weren’t instructed on how to treat the V.I.P. patients, the blanket spoke for itself: “This patient is important.” Today, I work at a hospital in Massachusetts that gives the same white blankets to everyone. Yet I continue to see red blanket patients. Here, they are called “pavilion patients” because they pay extra to stay in private hotel-like rooms on the top floor, which come with gourmet food, plush bath robes and small business centers. (Shoa L. Clarke, 10/26) For a century, the American Cancer Society has held up “early detection” of breast and other cancers as its mantra. Once, that made sense. But over the past few decades, the limitations of this approach have become increasingly apparent to researchers, physicians and other advocacy groups: Early detection
WHICH COUNTRIES IN EUROPE ARE EMBRACING ELECTRIC VEHICLES?Europe’s automotive market is slowly getting charged. The drivers of electrification are EU regulatory agencies, which are imposing ever-stricter limits on carbon and nitrogen oxide pollution. Meanwhile, the German auto industry is pulling in the other direction, using its immense political power to try to delay and water down emissions regulations. The various European countries are caught in the middle – some are embracing the electric future, some are resisting it, and most are muddling through with no particular plan.*This article comes to us courtesy of EVANNEX (which also makes aftermarket Tesla accessories). Authored by Charles Morris. The opinions expressed in these articles are not necessarily our own at InsideEVs. Above: Spain also hosts the Electric GT racing championships (Source: Electric GT)In the first half of 2018, 5,906 electrified vehicles were sold in Spain, nearly double the number registered in the first half of 2017, according to the industry association ANFAC, giving plug-in vehicles a market share of 0.8 percent.Spain has just over 5,000 charging stations, according to the latest estimate by the European Alternative Fuels Observatory. Spanish utility Iberdrola and French oil company Avia plan to invest 1.35 million euros in new charging points at 27 Avia gas stations. Iberdrola has also announced a plan to install 25,000 charging points by 2021.DENMARKDenmark has become the latest country to propose an eventual ban on the sale of ICE vehicles. In a recent speech to parliament, Prime Minister Lars Løkke Rasmussen said, “In just 12 years, we will prohibit the sale of new diesel and petrol cars. And in 17 years, every new car in Denmark must be an electric car or other forms of zero-emissions car.”The new policy represents an about-face for Denmark, which saw EV sales plummet after the government began phasing out incentives in 2015. Last year, plug-in vehicle sales represented just 0.4% of the Danish market, a pittance compared to the numbers in neighboring Sweden (5.3%) and Norway (39%).GERMANYAnd then there is Germany, home to the world’s largest automaker (VW) and some of the world’s most iconic luxury brands. The federal government is pushing – in 2010, Chancellor Angela Merkel set a goal of having one million electrified cars by 2020 – but the auto industry has been bravely holding back the tide. At the start of this year, there were around 100,000 plug-ins on German roads, just over half of them pure EVs. Above: A look back at the first Tesla Model S delivered in Europe to Norway’s Frederic Hauge (Image: EV Obsession)A recent article in Automotive News Europe examines the current state of play in the Continent’s most important auto markets.NORWAYNorway has become the world’s EV capital, thanks to generous purchase subsidies and other incentives. EVs are exempt from acquisition tax and from the country’s 25 percent value-added tax. They also enjoy privileged status on the roads, with exemptions from tolls, free ferry rides and, in some cities, free parking. Last year, pure electric cars accounted for over 20% of new registrations. Tesla’s Model X is by far the top seller – the Nissan LEAF is #2, and Model S is #3 (according to EV Sales).THE NETHERLANDSThe Netherlands holds a firm second place in the EV race. Plug-in vehicles accounted for some 4.1% of total auto sales so far this year. Tesla is the market leader here too – sales set a new record in September, with Model S in the lead, followed by Model X (and the Nissan LEAF in a distant third).UNITED KINGDOMThe UK aims to be a major force in the electric vehicle market, which it sees as a way to revitalize the country’s industry and provide high-tech jobs. Along with California (and possibly China), the UK is one of the few governments that has a comprehensive strategy for electrification, as opposed to the piecemeal measures being taken by most countries and states. The government’s Road to Zero strategy addresses commercial vehicles, public transport, charging infrastructure and much more, and includes a proposal to end the sale of fossil-powered vehicles by 2040. Source: Electric Vehicle News Above: Swiss Energy Minister Doris Leuthard’s Tesla (Image: Bilanz via @UVEK)Swiss Energy Minister Doris Leuthard (who drives a Model S) is an EV booster, but the federal government has soundly rejected every proposal for purchase incentives or investments in charging infrastructure. Over the past couple of years, Swiss auto importers paid around 18 million Swiss francs in fines for exceeding emissions standards, but the auto lobby recently introduced measures that could allow importers to continue to exceed the standards without incurring fines.===Written by: Charles Morris; Source: Automotive News Europe*Editor’s Note: EVANNEX, which also sells aftermarket gear for Teslas, has kindly allowed us to share some of
Source: Charge Forward The Volkswagen group is doing a 180-degree turn from their emission cheating days to pushing for CO2 neutral production of electric cars.In a new presentation, VW shows how the I.D., its first next-generation electric vehicle, will be “CO2 neutral throughout the entire life cycle if the customer consistently charges with green power.” more…The post Volkswagen is pushing for CO2 neutral production of electric cars appeared first on Electrek.
Source: Charge Forward Volvo Trucks announced it has delivered its first electric trucks to two customers in Sweden as part of a development program to bring the electric vehicles to market. more…The post Volvo delivers its first electric trucks appeared first on Electrek.
Kia Ceed Sportswagon PHEV expected this SeptemberSource: Electric Vehicle News
Source: Charge Forward Lotus has dropped a date for the debut of its all-electric hypercar — the Type 130 will be revealed in London on July 16. more…Subscribe to Electrek on YouTube for exclusive videos and subscribe to the podcast.https://www.youtube.com/watch?v=V1zk7Eb8r-s&list=PL_Qf0A10763mA7Byw9ncZqxjke6Gjz0MtThe post Lotus teases Type 130 all-electric hypercar with new video, debut coming July 16 appeared first on Electrek.
During the first five months, some 110,886 plug-in electric cars were sold, and almost 42% of them were Tesla Model 3.Source: Electric Vehicle News
Carter: ‘We have the grit to win another grand slam’ New Zealand rugby union team First published on Sun 2 Nov 2008 19.01 EST … we have a small favour to ask. The Guardian will engage with the most critical issues of our time – from the escalating climate catastrophe to widespread inequality to the influence of big tech on our lives. At a time when factual information is a necessity, we believe that each of us, around the world, deserves access to accurate reporting with integrity at its heart.More people are reading and supporting The Guardian’s independent, investigative journalism than ever before. And unlike many news organisations, we have chosen an approach that allows us to keep our journalism accessible to all, regardless of where they live or what they can afford. But we need your ongoing support to keep working as we do.Our editorial independence means we set our own agenda and voice our own opinions. Guardian journalism is free from commercial and political bias and not influenced by billionaire owners or shareholders. This means we can give a voice to those less heard, explore where others turn away, and rigorously challenge those in power.We need your support to keep delivering quality journalism, to maintain our openness and to protect our precious independence. Every reader contribution, big or small, is so valuable. Support The Guardian from as little as $1 – and it only takes a minute. Thank you. Share on Facebook Share on Pinterest Share via Email Sun 2 Nov 2008 19.01 EST Dan Carter. Photograph: Ross Land/Getty Images Support The Guardian Share via Email Share on Twitter Reuse this content Share on Facebook Dan Carter is confident New Zealand have the “grit, heart and character” required to complete a second grand slam tour of the British Isles in four years. The All Blacks have headed to Scotland after overhauling Australia 19-14 in Hong Kong to wrap up the 2008 Bledisloe Cup series 3-1. It was the second successive Test against the Wallabies in which New Zealand came from behind to win. New Zealand have completed two grand slam tours in their history – in 1978 and in 2005. Carter said: “It is good to know we have character within the side because it goes a long way when you are not playing as well as you would like.” The uncapped hooker Hikawera Elliot will replace Andrew Hore, who strained an ankle on Saturday. PA Topics Share on Messenger New Zealand rugby union team Autumn internationals Share on Twitter Shares00 Share on LinkedIn Share on WhatsApp Rugby union Since you’re here…
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Jul 16 2018Numerous studies to date have shown that olfactory receptors are relevant not only for smell perception, but that they also play a significant physiological and pathophysiological role in all organs. An overview of receptors detected so far and of the functions they fulfil within the human body is provided by Prof Dr Dr Dr habil. Hanns Hatt and Dr Désirée Maßberg from the Department for Cellphysiology at Ruhr-Universität Bochum, published in the journal Physiological Reviews; online preview available on June 13, 2018. They elaborate, for example, potential clinical applications, especially with regard to cancer diagnosis and therapy, and they discuss the steps scientists have yet to take to ensure that the receptors’ full potential can be used for applications in the medical field, but also in health and care products.Different cell biological effectsIn 2003, the team headed by Hanns Hatt demonstrated for the first time that olfactory receptors fulfil important functions in tissues outside of the nose; subsequently, the researchers in Bochum and in other labs successfully described the role of olfactory receptors in more than 20 different types of human tissue. Most up to date DNA sequencing methods were instrumental for the collection of new information about quantitative and specific distribution patterns. It emerged that 5 to 80 different types of olfactory receptors can be found per tissue.”Olfactory receptors outside the nose, however, don’t really have much to do with smelling as such,” says Hanns Hatt. “Rather, we should refer to them in more general terms, namely as chemoreceptors.” If a molecule activates such a receptor, it may stimulate the cells to multiply, move, or release specific chemical transmitters. Cell death is also affected by olfactory receptors. Cell-biological effects are many and varied precisely because olfactory receptors have the ability to switch on different signalling pathways in cells.Related StoriesNew shingles vaccine reduces outbreaks of painful rash among stem cell transplant patientsNew study reveals ‘clutch’ proteins responsible for putting T cell activation ‘into gear’New protein target for deadly ovarian cancerOlfactory receptors in cancer cellsCancer cells often contain specific olfactory receptors in large amounts – often different ones to those found in healthy cells. In their article, the authors from Bochum describe that olfactory receptors can thus be used as specific markers for tumours and their metastases and, consequently, be useful for cancer diagnosis. Moreover, Hatt and Maßberg consider them to have potential for cancer therapy, especially in the case of tumours that are easily accessible for odorants, e.g. in intestinal or bladder cancer.”In addition, applications in the field of wellness and healthcare are likewise conceivable,” elaborates Hanns Hatt. Skin regeneration, intestinal digestion, and hair growth can be regulated via olfactory receptors. This therapeutic method is already being applied for tissue repair and for promoting digestion.In-depth research necessaryIn order to exploit the receptors’ potential in the areas outlined above, the authors point out that ongoing in-depth research will remain necessary. “Unfortunately, the activating odorants of only about 50 of the 350 human olfactory receptors have been identified to date,” illustrates Hanns Hatt. He considers it an essential research goal to decode additional olfactory receptors, to find the relevant signaling pathways, and to shed light on the function of receptors in a living body.”Another major challenge is transferring basic-research findings into clinical applications,” explains Hatt. “In future, deploying odorants for activating or blocking receptors will open up a comprehensive and effective broad spectrum of novel therapeutic approaches in the field of pharmacology.” Source:http://news.rub.de/english/press-releases/2018-07-16-biology-olfactory-receptors-have-more-functions-merely-smell-perception
Jul 18 2018The components of the immune system that trigger allergic reactions may also help protect the skin against cancer, suggest new findings.The research, led by Imperial College London, highlights previously unknown skin defenses – and could open avenues for developing new skin cancer treatments.The early-stage study, published in the journal Nature Immunology, may also provide clues into why allergies are on the rise. Estimates suggest 44 per cent of Britons now suffer from at least one allergy – but the reasons behind the increase are unknown.The team behind the latest research suggest their findings support the so-called ‘Toxin Hypothesis’, which proposes that exposure to environmental toxins and chemicals foreign to our body may trigger allergic responses.The new research focuses on a type of antibody called Immunoglobulin E, or IgE. This protein, which is part of the immune system, triggers allergic reactions by mistakenly recognizing a harmless substance – such as peanuts – as a danger. A full-blown attack is launched by the body, under instruction from IgE, resulting in skin rashes, and swelling of face, mouth – and in severe cases – the airway.However, despite the actions of IgE having such serious consequences in the body, scientists are still puzzled by its original role – and whether it serves any useful purpose.The latest research suggests the antibody may have a crucial role in defending against the damage caused by environmental chemicals – and thereby protects against cancer. The IgE (triggered by the skin exposure to toxic agents) accumulates at the skin site, and prevents damaged cells from turning into cancerous tumors.Dr Jessica Strid, lead author of the study from the Department of Medicine at Imperial, explained: “IgE must have some important role in the body – but at the moment scientists are still unclear what it is. We used to think it protects us against parasites – such as intestinal worms – and the lack of worm infections is causing the allergy rise. However, after previous work suggested the body can still fight parasites without IgE, we don’t now believe this to be the only purpose.Related StoriesUsing machine learning algorithm to accurately diagnose breast cancerNew protein target for deadly ovarian cancerTrends in colonoscopy rates not aligned with increase in early onset colorectal cancer”Our new work suggests IgE could protect against the damage caused by skin exposure to tumor-promoting chemicals or UV irradiation – and help fight against skin cancer.”In the research, the team found that placing a toxic chemical on mouse skin caused IgE to be induced and travel to the site of damage. Once there, IgE lowered the risk of cancer development in the skin.They also studied skin tumors from 12 patients with squamous cell carcinoma – the second most common type of skin cancer.Results showed all tumors, some of which were more aggressive than others, had IgE present. Further analysis of a larger cohort of patients showed that less dangerous or ‘low risk’ tumors had more IgE-carrying cells, while more serious tumors had less, suggesting IgE may be offering some kind of protective effect against the progression of the cancer.Dr Strid added: “This is just the beginning of the story – our next step is to find out how exactly IgE may stop skin cells turning cancerous, and to see if we can somehow manipulate the allergic response to either protect against, or treat skin cancer.”She added that the findings also hint that allergies could be linked to chemicals in our modern environment.”Our work raises a lot of questions – and we now have to set about answering them. But the initial results support the so-called Toxin Hypothesis, which suggests that chemicals in the environment, such as those in air pollution, arising from industrial combustion and car emissions, as well as from tobacco smoke, could damage the skin and cause a rise in IgE. The theory suggests this rise in IgE may play a role in the alarming increase in allergies over the last decades.”She explained IgE may have evolved to kick into action when the skin touched something toxic. “It may be that the IgE would trigger a rash, or a stronger unpleasant response, when the skin contacts something potentially poisonous. This would send a clear message to the body saying this is harmful – don’t touch that again.” Source:https://www.imperial.ac.uk/news/187266/allergic-responses-linked-skin-cancer-protection/
Source:https://www.westmeadinstitute.org.au/news-and-events/2018/looking-inside-the-brain-to-distinguish-bipolar-fr Reviewed by Alina Shrourou, B.Sc. (Editor)Sep 4 2018New research has found that neurons deep inside the brain could hold the key to accurately diagnosing bipolar disorder and depression.The research team used sophisticated MRI scanning to see how the amygdala – a set of neurons that play a key role in processing emotions – reacts as a patient processes facial expressions such as anger, fear, sadness, disgust and happiness.The research showed that this key structure within the brain responds differently depending on whether the person has bipolar disorder or depression.In people with bipolar disorder, the left side of the amygdala is less active and less connected with other parts of the brain than in people with depression.Related StoriesResearchers measure EEG-based brain responses for non-speech and speech sounds in childrenAn active brain and body associated with reduced risk of dementiaStudy provides new insight into longitudinal decline in brain network integrity associated with agingThe findings from this study had 80% accuracy in making this distinction.Lead researcher Dr Mayuresh Korgaonkar from the Westmead Institute for Medical Research and the University of Sydney said these differences could potentially be used in the future to differentiate bipolar disorder from depressive disorders.”Mental illness, particularly bipolar disorder and depression, can be difficult to diagnose as many conditions have similar symptoms,” Dr Korgaonkar said.”These two illness are virtually identical except that in bipolar individuals also experience mania.”This means distinguishing them can be difficult and presents a major clinical challenge as treatment varies considerably depending on the primary diagnosis.”The wrong diagnosis can be dangerous, leading to poor social and economic outcomes for the patient as they undergo treatment for a completely different disorder.”Identifying brain markers that could reliably tell them apart would have immense clinical benefit.”Such a marker could help us better understand both these disorders, identify risk factors for developing these disorders, and potentially enable clear diagnosis from early onset,” Dr Korgaonkar said.Approximately 60% of patients with bipolar disorder are initially misdiagnosed as major depressive disorder.Alarming, it can take up to a decade for these patients to be accurately diagnosed with bipolar disorder.Bipolar disorder often first presents in the depressive phase of the illness and bipolar depression is similar to major depression in terms of clinical symptoms.Emotion processing is a core problem underlying both these disorders.Dr Korgaonkar and his team are now running phase 2 of this study, which aims to further characterize these identified markers in a larger cohort of patients.
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Robots—like people—use ‘imagination’ to learn concepts Instead of relying on a list of rules or training on a massive data set like standard computers, a new computational framework for learning lets robots come up with their own concepts by detecting abstract differences in images and then recreating them in real life. Watch the video to learn more. By Chris BurnsJan. 16, 2019 , 2:50 PM
ShareTweetSharePinNovak Djokovic saved two championship points in Wimbledon’s longest singles final to retain his title in a thrilling win over Roger Federer.On a Centre Court, with an atmosphere that felt at times more akin to football than tennis, Djokovic won 7-6 (7-5) 1-6 7-6 (7-4) 4-6 13-12 (7-3).As the clock ticked to four hours 57 minutes, Federer hit a ball high to hand the Serb victory.The world number one has won 16 Grand Slams – and four of the last five.“It’s quite unreal,” Djokovic said after winning his fifth Wimbledon title.Federer, who at 37 was chasing a record-equalling ninth Wimbledon singles title, added: “It was a great match, it was long, it had everything. Novak, congratulations, man, that was crazy.”Read more….. Simona Halep says controlling her nerves and forgetting about who she was playing enabled her to play the match of her life and win Wimbledon.The Romanian’s 56-minute 6-2 6-2 demolition of Serena Williams earned her a second Grand Slam title.“The nerves were positive this time. I felt them in the stomach,” she said. “I always play well when I have emotions.“I didn’t think at all against who I play. I’ve always been intimidated a little bit when I faced Serena.”Read more…
Ayodhya dispute: Mediation to continue till July 31, SC hearing likely from August 2 The six-meter (20 foot) high blimp was raised in Parliament Square at 0900 GMT. It is due to be airborne when Trump holds talks with the outgoing British Prime Minister Theresa May nearby in Downing Street.Trump and his wife Melania arrived on Monday for a three-day state visit – a pomp-laden affair that involved a banquet at Buckingham Palace on Monday evening. Leo Murray, 42, the co-creator of the blimp, said: “We’re trying to remind the president how unwelcome he is in this country.“We’re also, in a light-hearted way, trying to articulate the strength of feeling against Donald Trump and his politics of hate,” he said. “We want to put a smile on people’s faces as well as make a serious point.” In Britain, Trump’s ban on travel to the United States from several primarily Muslim countries, the decision to withdraw the United States from a global deal to combat climate change, and his criticism of British politicians have helped stoke opposition to his presidency.The state dinner held in the president’s honour was boycotted by several lawmakers, including the leader of Britain’s Liberal Democrat party as well as Corbyn and other senior Labour figures.The U.S. president’s supporters said it was an insult to snub the leader of Britain’s closest ally. But the demonstrators have received tactical support from Mayor of London Sadiq Khan, who has repeatedly clashed with the president and who gave permission to fly the blimp.The president called the mayor a “stone-cold loser” shortly before he arrived in Britain and has in the past accused him of failing to do enough to stop deadly terror attacks in London. The blimp, which was first used during Trump’s visit to London last year, rose a few meters off the ground. (AP)A giant inflatable blimp depicting Donald Trump as a pouting baby in a diaper flew outside the British parliament in London on Tuesday ahead of what is expected to be one of the city’s largest protests against a foreign leader. Unbowed, Trump intensifies attacks on four Democratic congresswomen Related News Hold the applause until Hafiz Saeed is convicted: US committee to Donald Trump Best Of Express By Reuters |London | Published: June 4, 2019 3:32:28 pm The blimp, which was first used during Trump’s visit to London last year, rose a few meters off the ground.In central London, the leader of Britain’s opposition Labour Party will join tens of thousands of protesters in a “Carnival of Resistance” to voice their opposition to the president.Jeremy Corbyn, who will speak at the rally after snubbing Monday night’s banquet at Buckingham Palace, said it was an “opportunity to stand in solidarity with those he’s attacked in America, around the world and in our own country”.Among those taking part will be environmental activists, anti-racism campaigners and women’s rights protesters. Police will close the road directly outside Downing Street to protect the president and his family. Advertising Advertising Post Comment(s) P Rajagopal, Saravana Bhavan founder sentenced to life for murder, dies US House rejects Saudi weapons sales; Trump to veto Chandrayaan-2 gets new launch date days after being called off